Domain

Chromosomal replication initiator, DnaA C-terminal (IPR013159)

Short name: DnaA_C

Overlapping homologous superfamilies

Domain relationships

None.

Description

This entry represents the C-terminal domain of bacterial DnaA proteins [PMID: 8110826, PMID: 1779750, PMID: 2558436] that play an important role in initiating and regulating chromosomal replication. DnaA is an ATP- and DNA-binding protein. It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC).

DnaA is a protein of about 50 kDa that contains two conserved regions: the first is located in the N-terminal half and corresponds to the ATP-binding domain, the second is located in the C-terminal half and could be involved in DNA-binding. The protein may also bind the RNA polymerase beta subunit, the dnaB and dnaZ proteins, and the groE gene products (chaperonins) [PMID: 2172087].

GO terms

Biological Process

GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication

Molecular Function

GO:0005524 ATP binding
GO:0043565 sequence-specific DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
CDD
Pfam