Domain

LEM-like domain (IPR013146)

Short name: LEM-like_dom

Domain relationships

Description

The LEM (LAP2, emerin, MAN1) domain is a globular module of approximately 40 amino acids, which is mostly found in the nucleoplasmic portions of metazoan inner nuclear membrane proteins. The LEM domain has been shown to mediate binding to BAF (barrier-to-autointegration factor) and BAF-DNA complexes.

All LAP2 isoforms also share an N-terminal segment composed of a LEM domain that is connected to a highly divergent LEM-like domain by a highly flexible 60- residue linker. The LEM-like globular domain has the same size and structural fold as the LEM domain, but has been shown to bind directly to DNA [PMID: 10671519, PMID: 11500367, PMID: 11435115].

This entry represents the LEM-like domain.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam