Conserved Site

Omega-atracotoxin, conserved site-2 (IPR013139)

Short name: Omega_atracotoxin_CS2

Description

Omega-atracotoxins (ACTX) form a family of neurotoxins that block insect but not vertebrate voltage-gated calcium channels. Omega-ACTXs are environmentally benign, insect-specific toxins that represent excellent leads for the development of new pesticides. Omega-ACTXs comprise a disulphide-rich region that has a [C-C-CC-C-C] arrangement and possess a Knottin scaffold [PMID: 9228949, PMID: 10491095, PMID: 14625686].

The omega-ACTX type 2 family contains 43 to 45-residue toxins with a disordered C-terminal lipophilic extension [PMID: 14625686]. This family includes omega-ACTX Hv2a from Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus), omega ACTX As2a, As2b from Atrax sp. Illawarra (Funnel-web spider), and omega ACTX Hi2a, Hi2b from Hadronyche infensa (Fraser island funnel-web spider).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns