Mannitol dehydrogenase, N-terminal (IPR013131)

Short name: Mannitol_DH_N

Overlapping homologous superfamilies

Domain relationships



Mannitol-1-phosphate 5-dehydrogenase catalyses the NAD-dependent reduction of mannitol-1-phosphate to fructose-6-phosphate [PMID: 1904856] as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates [PMID: 1322373]. Mannitol 2-dehydrogenase catalyses the NAD-dependent reduction of mannitol to fructose [PMID: 8254318]. Several dehydrogenases have been shown [PMID: 8254318] to be evolutionary related, including mannitol-1-phosphate 5-dehydrogenase (EC: (gene mtlD), mannitol 2-dehydrogenase (EC: (gene mtlK); mannonate oxidoreductase (EC: (fructuronate reductase) (gene uxuB); Escherichia coli hypothetical proteins ydfI and yeiQ; and yeast hypothetical protein YEL070w. This domain has a Rossmann-type fold.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.