Acetohydroxy acid isomeroreductase, NADPH-binding domain (IPR013116)

Short name: IlvN

Overlapping homologous superfamilies

Domain relationships



Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine. This N-terminal region of the enzyme carries the binding-site for NADPH. The active-site for enzymatic activity lies in the C-terminal part [PMID: 9218783, PMID: 16322583, PMID: 19362563].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.