Domain

EGF-like domain, extracellular (IPR013111)

Short name: EGF_extracell

Domain relationships

None.

Description

A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown [, PMID: 3282918, PMID: 6607417, PMID: 2288911, PMID: 6334307] to be present, in a more or less conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains in what appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulphide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet. Subdomains between the conserved cysteines vary in length.

This entry contains EGF domains found in a variety of extracellular and membrane proteins

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam