Tetratricopeptide repeat 2 (IPR013105)

Short name: TPR_2


The tetratrico peptide repeat (TPR) is a structural motif present in a wide range of proteins [PMID: 7667876, PMID: 9482716, PMID: 1882418]. It mediates protein-protein interactions and the assembly of multiprotein complexes [PMID: 14659697]. The TPR motif consists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. Sequence alignment of the TPR domains reveals a consensus sequence defined by a pattern of small and large amino acids. TPR motifs have been identified in various different organisms, ranging from bacteria to humans. Proteins containing TPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

This repeat includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by IPR001440.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.