Domain

BTB/POZ (IPR013069)

Short name: BTB_POZ

Domain relationships

Description

The BTB (for BR-C, ttk and bab) [PMID: 7938017] or POZ (for Pox virus and Zinc finger) [PMID: 7958847] domain is present near the N terminus of a fraction of zinc finger (IPR007087) proteins and in proteins that contain the IPR006652 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [PMID: 7958847]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [PMID: 9770450]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [PMID: 9019154, PMID: 9824158, PMID: 9765306]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam