Meiotic recombination, Spo11 (IPR013048)

Short name: Meiotic_Spo11

Overlapping homologous superfamilies

Family relationships


Spo11 is a meiosis-specific protein in yeast that covalently binds to DNA double-strand breaks (DSBs) during the early stages of meiosis [PMID: 10534401]. These DSBs initiate homologous recombination, which is required for chromosomal segregation and generation of genetic diversity during meiosis. Mouse and human homologues of Spo11 have been cloned and characterised. The proteins are 82% identical and share ~25% identity with other family members. Mouse Spo11 has been localised to chromosome 2H4, and human SPO11 to chromosome 20q13.2-q13.3, a region amplified in some breast and ovarian tumours [PMID: 10534401].

Similarity between SPO11 and archaebacterial TOP6A proteins points to evolutionary specialisation of a DNA-cleavage function for meiotic recombination [PMID: 10622720]. Note that the yeast SPO11 protein shares far less similarity to other SPO11 proteins than the human and mouse homologues do to each other.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.