Gamma-glutamyl cyclotransferase-like (IPR013024)

Short name: GGCT-like

Overlapping homologous superfamilies

Domain relationships


Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24 [PMID: 18515354]. The enzyme participates in the gamma-glutamyl cycle, which plays a pre-eminent role in glutathione homoeostasis [PMID: 6137189]. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism.

AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2 [PMID: 16754964, PMID: 8742710]. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. This GGCT-like domain is also found in bacterial tellurite-resistance proteins (TrgB) [PMID: 10203839], butirosin biosynthesis protein BtrG [PMID: 17462573], and in proteins described as ChaC, involved in a novel pathway for glutathione degradation [PMID: 23070364].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.