Family

DNA helicase (DNA repair), Rad3 type (IPR013020)

Short name: DNA_helicase_DNA-repair_Rad3

Family relationships

Description

Proteins in this family are DNA repair helicases, including Rad3/XPD family and Chl1/DDX11 family members. Rad3/XPD is a component of the TFIIH core complex, which is involved in excision repair of DNA damaged [PMID: 7961739, PMID: 8631896]. DDX11/Chl1 is important for normal cell cycle progression [PMID: 17611414, PMID: 10931920].

Defects in DDX11 are the cause of Warsaw breakage syndrome (WBRS). It is a syndrome characterised by severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation [PMID: 20137776].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs