ATP-dependent helicase Rad3/Chl1-like (IPR013020)

Short name: Rad3/Chl1-like

Overlapping homologous superfamilies


Family relationships


This entry includes a group of ATP-dependent helicases, including Rad3/XPD (ERCC2), Chl1/DDX11, DDX12, RTEL1 and BRIP1. Rad3/XPD is a subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3) [PMID: 7961739, PMID: 8631896]. DDX11/Chl1 is required for sister-chromatid cohesion [PMID: 17611414, PMID: 10931920, PMID: 15226378].

Defects in DDX11 are the cause of Warsaw breakage syndrome (WBRS). It is a syndrome characterised by severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation [PMID: 20137776].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004003 ATP-dependent DNA helicase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.