Domain

CHD, N-terminal (IPR012958)

Short name: CHD_N

Domain relationships

None.

Description

This entry represents the N-terminal domain of CHD (Chromodomain, Helicase, DNA-binding) proteins. CHD3 and CHD4 belong to the class II subfamily of CHD ATPases, and each is present as a core catalytic subunit in separate NuRD complexes, which regulate chromatin organisation and gene transcription [PMID: 23340908]. CHD5 forms a NuRD-type chromatin remodeling complex and acts as a tumour suppressor [PMID: 24419087].

There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a beta-sheet folded against an alpha-helix that collectively mediates binding to methyl-lysine residues [PMID: 23954449].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam