Domain

Centrosomin, N-terminal motif 1 (IPR012943)

Short name: Cnn_1N

Domain relationships

None.

Description

This domain (Cnn_1N) is a short conserved motif found in the N-terminal of a group of centrosome or spindle pole body (SPB) associated proteins, including Mto1 and Pcp1 from S. pombe [PMID: 15004232, PMID: 11864908], centrosomin from flies [PMID: 10357928, PMID: 24656740] and myomegalin/CDK5RAP2 from mammals [PMID: 18042621, PMID: 11134006].

In Drosophila, centrosomin (Cnn) is an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix (PCM) proteins to achieve microtubule-organising activity at mitosis. The Cnn_1N domain (motif 1 of Cnn) is necessary for proper recruitment of gamma-tubulin, D-TACC (the homologue of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila [PMID: 17671162].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005815 microtubule organizing center

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam