Domain

FAM46 family (IPR012937)

Short name: DUF1693

Domain relationships

None.

Description

The function of FAM46 family is not clear. FAM46 family members contain a NTase (nucleotidyltransferase) domain, some members possess additional C-terminal PAP/OAS1 substrate binding domain [PMID: 19833706]. They have different functions in many tissues at various stages of development. Human FAM46A is a SMAD signalling pathway related protein, where SMADs are intercellular effectors of transforming growth factor-beta (TGF-beta) [PMID: 19833706]. Human FAM46C seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon [PMID: 17803723].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART