Endoplasmic reticulum vesicle transporter, C-terminal (IPR012936)

Short name: Erv_C

Overlapping homologous superfamilies


Domain relationships



This entry represents the C-terminal domain of the endoplasmic reticulum vesicle transporter proteins.

Proteins included in this entry are conserved from plants and fungi to humans. Erv46 (ERGIC3) works in close conjunction with Erv41 (ERGIC2) and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localisation. All proteins identified biochemically as Erv41p-Erv46p interactors are localised to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi [PMID: 17077122].

Proteins containing this domain also include disulfide isomerase (PDI)-C subfamily members from Arabidopsis. They are chimeric proteins containing the thioredoxin (Trx) domain of PDIs, and the conserved N- and C-terminal Pfam domains of Erv cargo receptors [PMID: 28444333].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.