RTP801-like (IPR012918)

Short name: RTP801-like

Overlapping homologous superfamilies

Family relationships



RTP801, also known as REDD1, is the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene and is thought to be involved in various cellular processes [PMID: 11884613]. Both RTP801 and RTP801-like (REDD2) work downstream of AKT and upstream of TSC2 to inhibit mTOR, a serine/threonine kinase that plays an essential role in cell growth control [PMID: 15632201]. Two members of this family expressed by Drosophila melanogaster, Scylla (Q9NHN4) and Charybde (Q9NHN5), are designated as Hox targets [PMID: 11884613, PMID: 16423342].

GO terms

Biological Process

GO:0009968 negative regulation of signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.