Domain

RED-like, N-terminal (IPR012916)

Short name: RED_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain contains sequences that are similar to the N-terminal region of Red protein (Q13123). This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements [PMID: 10216252]. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region [PMID: 10216252], suggesting that these proteins are expressed in the nucleus [PMID: 10216252]. Protein RED (also known as IK) is found in the nucleus and is a component of the spliceosome [PMID: 28781166]. It is also associated with the spindle pole where it co-localizes with and interacts with the spindle assembly checkpoint protein MAD1 during metaphase and anaphase. Depletion of RED shortens the mitotic cycle and MAD1 is incorrectly localized [PMID: 22351768].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam