Protein serine/threonine phosphatase 2C, C-terminal (IPR012911)

Short name: PP2C_C

Overlapping homologous superfamilies

Domain relationships



Protein phosphatase 2C (PP2C, also known as Protein phosphatase 1) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteristic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain [PMID: 9003755].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0000287 magnesium ion binding
GO:0030145 manganese ion binding
GO:0004721 phosphoprotein phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.