GPI inositol-deacylase PGAP1-like (IPR012908)

Short name: PGAP1-like

Overlapping homologous superfamilies

Family relationships



The sequences found in this family are similar to PGAP1 (Q765A7). This is an endoplasmic reticulum membrane protein with a catalytic serine-containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body [PMID: 14734546].

This entry also includes Tgl2, a mitochondria protein that serves as a triacylglycerol lipase in budding yeasts [PMID: 19959834].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016788 hydrolase activity, acting on ester bonds

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.