Domain

8-oxoguanine DNA glycosylase, N-terminal (IPR012904)

Short name: OGG_N

Domain relationships

None.

Description

The presence of 8-oxoguanine residues in DNA can give rise to G-C to T-A transversion mutations. This enzyme is found in archaeal, bacterial and eukaryotic species, and is specifically responsible for the process which leads to the removal of 8-oxoguanine residues. It has DNA glycosylase activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18) [PMID: 10706276]. The region featured in this family is the N-terminal domain, which is organised into a single copy of a TBP-like fold. The domain contributes residues to the 8-oxoguanine binding pocket [PMID: 11902834].

GO terms

Biological Process

GO:0006289 nucleotide-excision repair

Molecular Function

GO:0003684 damaged DNA binding
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam