GC-rich sequence DNA-binding factor (IPR012890)

Short name: GCFC

Overlapping homologous superfamilies


Family relationships



Sequences found in this family are similar to a region of a human GC-rich sequence DNA-binding factor homologue (Q9Y5B6) and includes ILP1 from Arabidopsis thaliana. ILP1 and its orthologue in mouse have been shown to be repressors of cyclin genes. In Arabidopsis, all members of the CYCLINA2 family are repressed, and in mouse cyclin A2. The CYCLINA2 cyclins control endoreduplication, in which DNA is replicated but the cell cyle continues without cell division leading to polyploidy. ILP1 therefore regulates endoreduplication through control of CYCA2 expression in Arabidopsis [PMID: 17012601].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.