Domain

L-fucose isomerase, N-terminal-2 (IPR012889)

Short name: Fucose_isomerase_N2

Domain relationships

None.

Description

Proteins containing this domain are similar to L-fucose isomerase expressed by Escherichia coli (P11552, EC:5.3.1.3). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis, and converts an aldo-hexose to a ketose to prepare it for aldol cleavage. The enzyme is a hexamer, with each subunit being wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta- sheets with surrounding alpha helices. The active centre is shared between pairs of subunits related along the molecular three-fold axis, with domains 2 and 3 from one subunit providing most of the substrate-contacting residues [PMID: 9367760].

GO terms

Biological Process

GO:0006004 fucose metabolic process

Molecular Function

GO:0008736 L-fucose isomerase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam