ERp29, N-terminal (IPR012883)

Short name: ERp29_N

Overlapping homologous superfamilies

Domain relationships



ERp29 (P52555) is a ubiquitously expressed endoplasmic reticulum protein, and is involved in the processes of protein maturation and protein secretion in this organelle [PMID: 10727933, PMID: 11435111]. The protein exists as a homodimer, with each monomer being composed of two domains. The N-terminal domain featured in this family is organised into a thioredoxin-like fold that resembles the a domain of human protein disulphide isomerase (PDI) [PMID: 11435111]. However, this domain lacks the C-X-X-C motif required for the redox function of PDI; it is therefore thought that the function of ERp29 is similar to the chaperone function of PDI [PMID: 11435111]. The N-terminal domain is exclusively responsible for the homodimerisation of the protein, without covalent linkages or additional contacts with other domains [PMID: 11435111].

GO terms

Biological Process

GO:0009306 protein secretion

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005788 endoplasmic reticulum lumen

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.