Domain

Calcium binding and coiled-coil domain-like (IPR012852)

Short name: CALCOCO1-like

Domain relationships

None.

Description

Calcium-binding and coiled-coil domain-containing protein 1 (Calcoco1) from Mus musculus (Q8CGU1) binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1 (Q61026), and thus enhances transcriptional activation by a number of nuclear receptors. Calcoco1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region [PMID: 14690606].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam