Chlorocatechol 1,2-dioxygenase (IPR012817)

Short name: Chlorcchol_dOase

Overlapping homologous superfamilies

Family relationships



Members of this protein family are chlorocatechol 1,2-dioxygenases. This enzyme is a homodimeric intradiol dioxygenase that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part of the modified ortho-cleavage pathway which is a central oxidative bacterial pathway that channels chlorocatechols, derived from the degradation of chlorinated benzoic acids, phenoxyacetic acids, phenols, benzenes, and other aromatics into the energy-generating tricarboxylic acid pathway [PMID: 16030237].

This protein is closely related to catechol 1,2-dioxygenase, IPR012801, EC: [PMID: 10730195]. Note: a number of annotated database entries for members of this family have EC numbers that refers to IPR012801; whereas members of this family acts in pathways for the biodegradation of chlorinated aromatic compounds.

GO terms

Biological Process

GO:0006725 cellular aromatic compound metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0018575 chlorocatechol 1,2-dioxygenase activity
GO:0005506 iron ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.