DNA-directed RNA polymerase subunit A'' (IPR012757)

Short name: RNAP_A2

Overlapping homologous superfamilies


Family relationships



DNA-directed RNA polymerases,also known as DNA-dependent RNA polymerases, are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. Eukaryotes have three different DNA-directed RNA polymerases (RNAPs), Pol I, II, and III, whereas Archaea and Bacteria have single enzymes.

RNAPs are multisubunit enzymes. Archaeal RNAP is closely related to eukaryotic RNAP II [PMID: 19880312], which consists of 12 subunits. Archaeal RNAP has an additional subunit, Rpo13, with no orthologue in the eukaryotic enzyme [PMID: 19419240].

This family consists of the archaeal A'' subunit of the DNA-directed RNA polymerase. The name Rpo1C has been proposed for this subunit based on eukaryotic terminology [PMID: 19419240].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.