Dihydroxyacetone kinase (IPR012734)

Short name: DhaK_ATP

Overlapping homologous superfamilies


Family relationships



This family consists of examples of the single chain form of dihydroxyacetone kinase (also called glycerone kinase) that uses ATP (EC: as the phosphate donor, rather than a phosphoprotein as in Escherichia coli. This form has separable domains homologous to the K and L subunits of the E. coli enzyme, and is found in yeasts and other eukaryotes and in some bacteria, including Citrobacter freundii [PMID: 7635824, PMID: 12966101].

The member from tomato has been shown to phosphorylate dihydroxyacetone, 3,4-dihydroxy-2-butanone, and some other aldoses and ketoses [PMID: 11985845]. Members from mammals have been shown to catalyse both the phosphorylation of dihydroxyacetone and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate [PMID: 16289032]. In yeast there are two isozymes of dihydroxyacetone kinase (Dak1 and Dak2). They are required for detoxification of dihydroxyacetone (DHA) [PMID: 10091325].

GO terms

Biological Process

GO:0006071 glycerol metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0004371 glycerone kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.