T-complex protein 1, gamma subunit (IPR012719)

Short name: Chap_CCT_gamma

Overlapping homologous superfamilies

Family relationships


Proteins in this entry consist exclusively of the CCT gamma chain from animals, plants, fungi, and other eukaryotes.

Members of this eukaryotic family are part of the group II chaperonin complex called CCT (chaperonin containing TCP-1 or Tailless Complex Polypeptide 1) or TRiC [PMID: 1352857, PMID: 15335898]. Chaperonins are involved in productive folding of proteins [PMID: 11340060]. They share a common general morphology, a double toroid of 2 stacked rings. The archaeal equivalent group II chaperonin is often called the thermosome [PMID: 11580264]. Both the thermosome and the TCP-1 family of proteins are weakly, but significantly [PMID: 1352040], related to the cpn60/groEL chaperonin family (see IPR001844).

The TCP-1 protein was first identified in mice where it is especially abundant in testis but present in all cell types. It has since been found and characterised in many other animal species, as well as in yeast, plants and protists. The TCP1 complex has a double-ring structure with central cavities where protein folding takes place [PMID: 20194787]. TCP-1 is a highly conserved protein of about 60kDa (556 to 560 residues) which participates in a hetero-oligomeric 900kDa double-torus shaped particle [PMID: 1630492] with 6 to 8 other different, but homologous, subunits [PMID: 7601114]. These subunits, the chaperonin containing TCP-1 (CCT) subunit beta, gamma, delta, epsilon, zeta and eta are evolutionary related to TCP-1 itself [PMID: 7953530, PMID: 7846767]. Non-native proteins are sequestered inside the central cavity and folding is promoted by using energy derived from ATP hydrolysis [PMID: 10753735, PMID: 10550210, PMID: 12354605]. The CCT is known to act as a molecular chaperone for tubulin, actin and probably some other proteins [PMID: 18595008, PMID: 15027029].

GO terms

Biological Process

GO:0006457 protein folding

Molecular Function

GO:0005524 ATP binding
GO:0051082 unfolded protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.