Prefoldin subunit beta (IPR012713)

Short name: PfdB

Overlapping homologous superfamilies

Family relationships


Chaperonins are cytosolic, ATP-dependent molecular chaperones, with a conserved toroidal architecture, that assist in the folding of nascent and/or denatured polypeptide chains. The group I chaperonin system consists of GroEL and GroES, and are found (usually) in bacteria and eukaryotic organelles. The group II chaperonin system, called the thermosome in archaea and TRiC or CCT in the Eukaryota, is structurally similar but only distantly related. Prefoldin, also called GimC, is a complex in archaea and eukaryota that works with group II chaperonins. Members of this protein family are the archaeal clade of the beta class of prefoldin subunit. Closely related, but outside the scope of this family are the eukaryotic beta-class prefoldin subunits, Gim-1,3,4 and 6. The alpha class prefoldin subunits are more distantly related [PMID: 10581246].

GO terms

Biological Process

GO:0006457 protein folding

Molecular Function

GO:0051082 unfolded protein binding

Cellular Component

GO:0016272 prefoldin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.