Lacto-N-biose phosphorylase/D-galactosyl-beta-1->4-L-rhamnose phosphorylase (IPR012711)

Short name: Lacto-N-biose_phosphorylase

Overlapping homologous superfamilies


Family relationships



This entry includes a group of bacterial phosphorylases, including lacto-N-biose phosphorylase (lnpA) from Bifidobacterium [PMID: 19124470] and D-galactosyl-beta-1->4-L-rhamnose phosphorylase (Cphy_1920) from Lachnoclostridium phytofermentans [PMID: 19491100].

lnpA can reversibly phosphorolyzes lacto-N-biose to Gal1-P and N-acetylglucosamine (GlcNAc) and galacto-N-biose to Gal1-P and N-acetylgalactosamine (GalNAc). It is involved in the lacto-N-biose I/galacto-N-biose (LNB/GNB) degradation pathway, which is important for host intestinal colonization by bifidobacteria [PMID: 15933016].

Cphy_1920 can reversibly phosphorolyzes beta-D-galactosyl-(1->4)-L-rhamnose to form alpha-D-galactose 1-phosphate and L-rhamnose. But it does not phosphorolyze galacto-N-biose or lacto-N-biose [PMID: 19491100].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004645 phosphorylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.