Pathways & interactions
4-hydroxyphenylacetate permease (IPR012707)
Short name: HPA_permease
Overlapping homologous superfamilies
- MFS transporter superfamily (IPR036259)
- Major facilitator superfamily (IPR011701)
- 4-hydroxyphenylacetate permease (IPR012707)
Among the different families of transporter only two occur ubiquitously in all classifications of organisms. These are the ATP-Binding Cassette (ABC) superfamily and the Major Facilitator Superfamily (MFS). The MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients [PMID: 9529885, PMID: 9868370].
This entry represents a group of MFS proteins encoded in a number of proteobacterial genomes, but only in the context of having genes for 4-hydroxyphenylacetate (4-HPA) degradation. The protein is characterised as 4-HPA permease in Escherichia coli, where 3-HPA and 3,4-dihydroxyphenylacetate, but not other substrate analogues, were shown to competitively inhibit 4-HPA transport, indicating a narrow substrate specificity [PMID: 9315705].
- TIGR02332 (HpaX)