4-hydroxyphenylacetate permease (IPR012707)

Short name: HPA_permease

Overlapping homologous superfamilies

Family relationships


Among the different families of transporter only two occur ubiquitously in all classifications of organisms. These are the ATP-Binding Cassette (ABC) superfamily and the Major Facilitator Superfamily (MFS). The MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients [PMID: 9529885, PMID: 9868370].

This entry represents a group of MFS proteins encoded in a number of proteobacterial genomes, but only in the context of having genes for 4-hydroxyphenylacetate (4-HPA) degradation. The protein is characterised as 4-HPA permease in Escherichia coli, where 3-HPA and 3,4-dihydroxyphenylacetate, but not other substrate analogues, were shown to competitively inhibit 4-HPA transport, indicating a narrow substrate specificity [PMID: 9315705].

GO terms

Biological Process

GO:1900754 4-hydroxyphenylacetate transport

Molecular Function

GO:1901241 4-hydroxyphenylacetate transmembrane transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.