2-methylcitrate dehydratase PrpD (IPR012705)

Short name: 2Me_IsoCit_deHydtase_PrpD

Overlapping homologous superfamilies

Family relationships

  • MmgE/PrpD (IPR005656)
    • 2-methylcitrate dehydratase PrpD (IPR012705)


At least five distinct pathways exist for the catabolism of propionate by way of propionyl-CoA. Most members of this family are bacterial proteins known or predicted to act as 2-methylcitrate dehydratase; an enzyme which catalyses the third step the methylcitrate cycle of propionate catabolism [PMID: 11294638]. A related clade of archaeal proteins that may or may not be functionally equivalent is excluded from this family. The PrpD enzyme of Escherichia coli is responsible for the minor aconitase activity (AcnC) not accounted for by AcnA and AcnB [PMID: 11782506]. Some proteins in this entry are annotated as MmgE, a Bacillus subtilis protein encoded within an operon which is expressed during sporulation, subject to catabolite repression [PMID: 8759838].

GO terms

Biological Process

GO:0019629 propionate catabolic process, 2-methylcitrate cycle

Molecular Function

GO:0051537 2 iron, 2 sulfur cluster binding
GO:0047547 2-methylcitrate dehydratase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.