Phosphonate metabolism PhnM (IPR012696)

Short name: PhnM

Overlapping homologous superfamilies

Family relationships



This family refers to Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase (also known as RPnTP diphosphatase or PhnM). PhnM is associated with phosphonate utilization in a number of bacterial species. It catalyzes the hydrolysis of alpha-D-ribose 1-methylphosphonate triphosphate (RPnTP) to form alpha-D-ribose 1-methylphosphonate phosphate (PRPn) and diphosphate [PMID: 22089136]. It is one of seven gene products (PhnG-PhnM) that participate in the catalysis of degradation of alkylphosphonates and are components of membrane associated C-P lyase complex [PMID: 11952414].

C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage of alkylphosphonates, which are utilized as sole phosphorus sources by many bacteria.

GO terms

Biological Process

GO:0019700 organic phosphonate catabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.