Domain

Transcription regulator Myc, N-terminal (IPR012682)

Short name: Tscrpt_reg_Myc_N

Domain relationships

None.

Description

The class III basic helix-turn-helix (bHLH) transcription factors have proliferative and apoptotic roles and are characterised by the presence of a leucine zipper adjacent to the bHLH domain. The myc oncogene gene was first discovered in small-cell lung cancer cell lines where it is found to be deregulated [PMID: 2827002]. Although the biochemical function of the gene product is unknown, as a nuclear protein with a short half-life it may play a direct or indirect role in controlling gene expression [PMID: 3018999]. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication [PMID: 9175477].

This entry represents the N-terminal domain found adjacent to the basic helix-loop-helix (bHLH) region (IPR011598).

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 transcription factor activity, sequence-specific DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam