Nucleobase cation symporter-1, NCS1 (IPR012681)

Short name: NCS1

Overlapping homologous superfamilies

Family relationships


The Nucleobase Cation Symporter-1 (NCS1) family are H+/Na+ symporters specific for the uptake of purines, pyrimidines and related metabolites ( This entry consists of bacterial and yeast transporters of the NCS1 family. Members of this family possess twelve putative transmembrane alpha-helical spanners (TMSs).

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0022857 transmembrane transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.