Family

Parabutoxin (IPR012635)

Short name: Parabutoxin

Family relationships

None.

Description

This entry represents proteins that are acidic alpha-KTx short chain scorpion toxins. These toxins are named parabutoxins, that binds and inhibit voltage-sensitive potassium channels and inhibit the vertebrate potassium channel Kv1.1 with low affinity. Furthermore, they lack the crucial pore-plugging lysine. In addition, the second important residue of the dyad, the hydrophobic residue (Phe or Tyr) is also missing [PMID: 14561751].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

GO:0019870 potassium channel inhibitor activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
Pfam