Domain

Peptidase C1A, propeptide (IPR012599)

Short name: Propeptide_C1A

Domain relationships

None.

Description

This domain is found at the N-terminal of cathepsin B and cathepsin B-like peptidases that belong to MEROPS peptidase subfamily C1A. Cathepsin B are lysosomal cysteine proteinases belonging to the papain superfamily and are unique in their ability to act as both an endo- and an exopeptidases. They are synthesized as inactive zymogens. Activation of the peptidases occurs with the removal of the propeptide [PMID: 7890671, PMID: 8740363].

GO terms

Biological Process

GO:0050790 regulation of catalytic activity

Molecular Function

GO:0004197 cysteine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam