Family

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (IPR012576)

Short name: NDUFB3

Family relationships

None.

Description

NADH:ubiquinone oxidoreductase (complex I) (EC:1.6.5.3) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [PMID: 10940377], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [PMID: 18394423].

This family represents an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain [PMID: 12611891].

GO terms

Biological Process

GO:0022900 electron transport chain

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005747 mitochondrial respiratory chain complex I
GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER