NADH:ubiquinone oxidoreductase, MNLL subunit (IPR012575)

Short name: NADH_UbQ_OxRdtase_MNLL_su

Overlapping homologous superfamilies


Family relationships



NADH:ubiquinone oxidoreductase (complex I) (EC: is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [PMID: 10940377], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [PMID: 18394423].

This family consists of the MNLL subunits of NADH:ubiquinone oxidoreductase complex [PMID: 15581635]. MNLL subunit is one of the many subunits found in the complex and it contains a mitochondrial import sequence. However, the role of MNLL subunit is unclear [PMID: 12644575].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003954 NADH dehydrogenase activity

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.