Domain

Ferlin B-domain (IPR012561)

Short name: Ferlin_B-domain

Domain relationships

None.

Description

The ferlin gene family are characterised by multiple tandem C2 domains and a C-terminal transmembrane domain. They are found in a wide range of species and their function remains unknown, however, mutations in its two most well-characterised members, dysferlin and otoferlin, have been implicated in human disease [PMID: 20667140].

This is central domain B in proteins of the Ferlin family [PMID: 15112237].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam