Repeat

Actin-binding, Xin repeat (IPR012510)

Short name: Actin-binding_Xin_repeat

Description

The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein (Q702N9) [PMID: 16631741]. The homologues in mouse and chicken localise in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localise with Vinculin which is known to attach the actin to the cytoplasmic membrane [PMID: 16631741]. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filamin C [PMID: 12203715]. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization

Molecular Function

GO:0003779 actin binding

Cellular Component

GO:0030054 cell junction

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles