Alpha-A conotoxin PIVA-like (IPR012498)

Short name: Toxin_14

Overlapping homologous superfamilies


Family relationships



Alpha-A conotoxin PIVA (P55963) is the major paralytic toxin found in the venom produced by the piscivorous snail Conus purpurascens. This peptide acts by blocking the acetylcholine-binding site of the nicotinic acetylcholine receptor at the neuromuscular junction [PMID: 7673220]. The overall shape of the peptide is described as an "iron" with a highly charged hydrophilic loop of 15S-19R forming the "handle" domain that is exposed to the exterior of the protein. The stability of the conotoxin is primarily governed by three disulphide bonds. A triangular structural motif formed by residues 19R, 12H and 6Y is thought to constitute a "binding core" that is important in binding to the acetylcholine receptor [PMID: 9048550].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

GO:0030550 acetylcholine receptor inhibitor activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.