TMC domain (IPR012496)

Short name: TMC_dom

Overlapping homologous superfamilies


Domain relationships



These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 (Q7TN63) and EVIN2 (Q8IU68) - this region is termed the TMC domain [PMID: 12906855]. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis [PMID: 12906855]. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters [PMID: 12812529].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.