Nuclease A inhibitor-like (IPR012489)

Short name: NucleaseA_inhib-like

Overlapping homologous superfamilies

Family relationships



This family consists of protein sequences that are similar to the nuclease A inhibitor expressed by bacteria of the genus Anabaena (NuiA, Q44296). This sequence is organised to form an alpha-beta-alpha sandwich fold, which is similar to the PR-1-like fold. NuiA interacts with nuclease A by means of residues located at one end of the molecule, including residues making up the loop between helices III and IV and the loop between strands C and D. The mechanism of inhibition of nuclease A by NuiA is as yet incompletely understood [PMID: 12095254].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.