Centromere protein I (IPR012485)

Short name: CENP-I

Overlapping homologous superfamilies


Family relationships



Centromere protein I (CENP-I) is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation [PMID: 12640463]. It may be involved in incorporation of newly synthesized CENP-A into centromeres via its interaction with the CENPA-NAC complex [PMID: 16622420]. In humans, CENP-I is required for the localisation of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores and is involved in the response of gonadal tissues to follicle-stimulating hormone [PMID: 11970896].

The CENP-I homologue in Schizosaccharomyces pombe, Mis6, is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant; an important event for centromere function and chromosome segregation during mitosis [PMID: 9230309, PMID: 10864871].

GO terms

Biological Process

GO:0034508 centromere complex assembly

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000776 kinetochore

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.