Kanamycin nucleotidyltransferase, C-terminal (IPR012481)

Short name: KNTase_C

Overlapping homologous superfamilies


Domain relationships



Kanamycin nucleotidyltransferase (KNTase) is involved in conferring resistance to aminoglycoside antibiotics and catalyses the transfer of a nucleoside monophosphate group from a nucleotide to kanamycin. This enzyme is dimeric with each subunit being composed of two domains. The C-terminal domain contains five alpha helices, four of which are organised into an up-and-down alpha helical bundle. Residues found in this domain may contribute to this enzyme's active site [PMID: 7577914].

GO terms

Biological Process

GO:0046677 response to antibiotic

Molecular Function

GO:0016779 nucleotidyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.