Family

Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2 (IPR012462)

Short name: Peptidase_C78_UfSP1/2

Overlapping homologous superfamilies

None.

Family relationships

  • Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2 (IPR012462)

Description

This entry contains UfSP1 and UfSP2, which are cysteine peptidases required for the processing and activation of Ubiquitin fold modifier 1 (Ufm1, IPR005375) and for its release from conjugated cellular proteins. UfSP1 and UfSP2 are 217 aa and 461 aa respectively [PMID: 15071506, PMID: 17182609]. The peptidases belong to MEROPS peptidase family C78, clan CA. The UfSP2 family have an N-terminal extension with one or more zinc finger domains of the C2H2 type, which have been shown to be involved in protein:protein interaction. UfSP2 is present in most, if not all, multi-cellular organisms including plants, nematodes, flies, and mammals, whereas UfSP1 is not present in plants and nematodes [PMID: 17182609].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam