Calcium release-activated calcium channel protein (IPR012446)

Short name: CRAC_channel

Overlapping homologous superfamilies

Family relationships

  • Calcium release-activated calcium channel protein (IPR012446)


This entry includes Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 green fluorescent protein (GFP) reporters are co-expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1-related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins [PMID: 17218360].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.