BDS potassium channel toxin (IPR012414)

Short name: BDS_K_chnl_tox

Overlapping homologous superfamilies

Family relationships



This entry represents the sea anemone type 3 (BDS) potassium channel toxins. Family members include toxin APETx1 and 2, and the antihypertensive and antiviral proteins BDS-I (P11494) and BDS-II (P59084) expressed by Anemonia sulcata. BDS-I is organised into a triple-stranded antiparallel beta-sheet, with an additional small antiparallel beta-sheet at the N terminus [PMID: 2566326]. The proteins are known to specifically block the Kv3.4 potassium channel, and thus bring about a decrease in blood pressure [PMID: 9506974]. Moreover, they inhibit the cytopathic effects of mouse hepatitis virus strain MHV-A59 on mouse liver cells, by an unknown mechanism [PMID: 2566326].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

GO:0008200 ion channel inhibitor activity
GO:0090729 toxin activity

Cellular Component

GO:0042151 nematocyst

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.