Family

Cyclin Y (IPR012399)

Short name: Cyclin_Y

Family relationships

None.

Description

Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [PMID: 12910258], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.

Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [PMID: 11056549].

This group represents cyclin Y (also known as cyclin X) and related cyclins. Cyclin Y is a positive regulatory subunit of the cyclin-dependent kinase CDK14/PFTK1. Cyclin Y acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway [PMID: 19524571, PMID: 20059949].

GO terms

Biological Process

GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity

Molecular Function

GO:0019901 protein kinase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF